Case Report
99mTc-HMDP Bone Scintigraphy and Paget's Disease: About 7 Cases in the Nuclear Medicine Department of Idrissa Pouye General Hospital in Dakar
El Hadji Amadou Lamine Bathily*,
Olatounde Herbert Fachinan,
Ousseynou Diop,
Mamoudou Salif Djigo,
Gora Thiaw,
Kalidou Gueye,
Mohamed Chekhma,
Boucar Ndong,
Omar Ndoye,
Mamadou Mbodj
Issue:
Volume 12, Issue 1, June 2024
Pages:
1-5
Received:
13 January 2024
Accepted:
30 January 2024
Published:
5 February 2024
Abstract: Paget's disease is a chronic disorder of the adult skeleton characterized by focal dys-regulation of bone remodelling. The aim of this study was to demonstrate the contribution of bone scintigraphy to the diagnosis of Paget's disease. The study was observational, cross-sectional and descriptive. It included patients who underwent bone scintigraphy in the nuclear medicine department of Dakar's Idrissa Pouye General Hospital from January 2020 to June 2023, and whose results suspected or confirmed Paget's disease of the bone. We collected a total of seven (07) patients during the study period, six (06) of whom were male with an average age of 67.42 years. Two (02) reasons justified the performance of scintigraphy in these patients. These were suspicion of Paget's disease and assessment of bone extension of prostate cancer with incidental discovery of Paget's disease. Two patients (28.57% of cases) had the monostotic form and five (71.43% of cases) had the polyostotic form. All lesions found on bone scans were hyper-fixating. Three (03) patients showed bone deformities, notably deformities of the long bones, and two (02) had typical osteocondensing (hyperfixation) images of the vertebrae, giving them a "Mickey Mouse" or clover appearance. Whole-body bone scintigraphy has made an important contribution to the diagnosis and assessment of the extent of Paget's disease, with a favourable dosimetric ratio.
Abstract: Paget's disease is a chronic disorder of the adult skeleton characterized by focal dys-regulation of bone remodelling. The aim of this study was to demonstrate the contribution of bone scintigraphy to the diagnosis of Paget's disease. The study was observational, cross-sectional and descriptive. It included patients who underwent bone scintigraphy ...
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Review Article
99mTc-Mibi Parathyroid Scintigraphy in the Exploration of Hyperparathyroidism in Senegal: A Study of 66 Cases in the Idrissa Pouye General Hospital, Dakar
El Hadji Amadou Lamine Bathily*,
Gora Thiaw,
Ousseynou Diop,
Mamoudou Salif Djigo,
Kalidou Gueye,
Dioudé Diaw,
Olatounde Herbert Fachinan,
Mohamed Chekhma,
Boucar Ndong,
Omar Ndoye,
Mamadou Mbodj
Issue:
Volume 12, Issue 1, June 2024
Pages:
6-14
Received:
14 January 2024
Accepted:
31 January 2024
Published:
5 February 2024
Abstract: Hyperparathyroidism is a common endocrinopathy, and parathyroid scintigraphy is part of the preoperative work-up. A prerequisite for adenoma surgery is precise localization of the pathological gland(s) concerned. Our aim was to review the parathyroid scans performed for hyperparathyroidism in Senegal. We carried out a retrospective study over a period of 2.5 years, including patients with hyperparathyroidism who underwent parathyroid scintigraphy with 99mTc-MIBI, in the nuclear medicine department of the Idrissa Pouye General Hospital in Dakar. A total of 66 patients were included. The mean age was 52 years, with a sex ratio (M/F) of 0.34. The majority of patients were from the capital, Dakar (93%). Primary hyperparathyroidism was the predominant indication (70%). Most patients were symptomatic. Mean parathyroid hormone (PTH) and Calcemia were 464 pg/ml and 98 mg/l respectively. Ultrasound revealed a thyroid nodule in 35% of cases. The scintigraphy was in favour of parathyroid adenoma (30%) with a predominant right upper location (right P4) (35%) and poor concordance between cervical ultrasound and parathyroid scintigraphy was observed with a kappa coefficient k=0.04. Parathyroid scintigraphy with 99mTc-MIBI allows precise localization of hyper functioning glands, enabling unilateral or minimally invasive cervical surgery to be adopted and reducing the therapeutic failure rate.
Abstract: Hyperparathyroidism is a common endocrinopathy, and parathyroid scintigraphy is part of the preoperative work-up. A prerequisite for adenoma surgery is precise localization of the pathological gland(s) concerned. Our aim was to review the parathyroid scans performed for hyperparathyroidism in Senegal. We carried out a retrospective study over a per...
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Research Article
Fatty Acid Composition and Physicochemical Properties of Ricinus communis Seed Oil Grown from Jabi Tehinan Woreda, Ethiopia
Issue:
Volume 12, Issue 1, June 2024
Pages:
15-20
Received:
13 February 2024
Accepted:
26 March 2024
Published:
12 April 2024
Abstract: Castor seed oil is well known for its diverse medicinal and industrial uses. It is widely utilized as an additive in foods, medicine, personal care goods, lubricant and biodiesel. Nonetheless, the oil content and physicochemical properties of castor seeds depend on their genotypic varieties and geographical location. Fortunately, Ethiopia is endowed with varieties of castor seeds. However, there is a limited research on the total oil content and quality of castor seeds oil. Thus, the aim of this study was to examine the total oil content, the physicochemical characteristics and fatty acid composition of castor seeds oil grown in Jabi Tehinan Woreda, Ethiopia. The three most populous genotype castor beans were collected and subjected to soxhlet extraction using hexane solvent. The outcome showed that their genotypes determine both the amount and quality of the oil extracted. Genotype 01 (GT-01) has exceptionally the highest oil content (69.8%) while the Genotype 02 (GT-02) (47.305) and Genotype 03 (GT-03) (43.21%) have high oil contents. GT-01 has the highest (87.49%), GT-02 the second (85.17) and GT-01 (84.01) the third ricinoleic acid component. This high ricinoleic acid composition is reflected on their chemical and physical properties which are in the range of ASTM standards, making them valuable for various industrial applications.
Abstract: Castor seed oil is well known for its diverse medicinal and industrial uses. It is widely utilized as an additive in foods, medicine, personal care goods, lubricant and biodiesel. Nonetheless, the oil content and physicochemical properties of castor seeds depend on their genotypic varieties and geographical location. Fortunately, Ethiopia is endowe...
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Fekadu Wubatu Fenta
