Volume 2, Issue 5, October 2014, Page: 49-60
Selective Mitophagy in Budding Yeast, a Mitochondrial Self-Eating Quality Control
Ziyad Tariq Muhseen, Key Laboratory of Molecular Biophysics, Department of Biotechnology, College of Life Science and Technology, Huazhong University of Science and Technology, 1037 Luoyu Rd., Wuhan 430074, Hubei, China
Received: Aug. 11, 2014;       Accepted: Aug. 26, 2014;       Published: Nov. 10, 2014
DOI: 10.11648/j.ejb.20140205.11      View  2694      Downloads  181
Mitochondria are responsible for the essential role in the cell survival by regulating the cellular energy, homeostasis, oxidative phosphorylation process, fatty acid oxidation and in the cell death process by regulating apoptosis. However, reactive oxygen species (ROS) is produced by mitochondria that pose oxidative damage to lipids, protein and mitochondrial DNA and additional production of ROS is triggered by this damage. On the other hand, the host cell control the life and death of mitochondria that include degradation, fission and growth. Recent research has been focused on the autophagic degradation of mitochondria, which is also mitophagy that results in significant discovery of the mechanism, function and regulation of mitophagy in eukaryotic cell especially in budding yeast. Mitophagy has been found to be important quality control mechanism for mitochondria. It has a key role in the eliminating of damaged mitochondria. Many studies have been done to unravel the mechanism and regulatory features of proteins involved in mitophagy but the results are inconsistent and conflicting. Mitochondrial surface receptor involved in mitochondrial autophagy has been recently identified using yeast genetics. Recent studies have been discovered specific regulators of Mitophagy that ensure selective sequestration of mitochondria as cargo. According to our understanding, in this paper we will review recent advances of different pathways of Mitophagy in the yeast. We will review the main proteins which play an essential role in controlling this process and the main pathways which lead to a highly controlled Mitophagy process.
Mitochondria, Mitophagy, Yeast, Autophagy
To cite this article
Ziyad Tariq Muhseen, Selective Mitophagy in Budding Yeast, a Mitochondrial Self-Eating Quality Control, European Journal of Biophysics. Vol. 2, No. 5, 2014, pp. 49-60. doi: 10.11648/j.ejb.20140205.11
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